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MedChemExpress
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Journal: International Journal of Molecular Sciences
Article Title: R-Propranolol Has Broad-Spectrum Anti-Coronavirus Activity and Suppresses Factors Involved in Pathogenic Angiogenesis
doi: 10.3390/ijms24054588
Figure Lengend Snippet: Effect of R-propranolol and S-propranolol on SARS-CoV-2-induced cytopathic effect in Vero E6 cells. CPE reduction assays were carried out on Vero E6 cells infected with SARS-CoV-2 (MOI of 0.015). Cells were pretreated with and infected in the presence of ( a ) R-propranolol, or ( b ) S-propranolol. At 72 hpi, cell viability was determined by MTS assay. n = 2 independent experiments. Cell viability of uninfected compound-treated cells was measured in parallel to assess the cytotoxicity of the compound. Mean ± SEM is shown. The 50% inhibitory concentration (IC50) was determined by non-linear regression with GraphPad Prism 6.
Article Snippet: R-(
Techniques: Infection, MTS Assay, Concentration Assay